Original Articles
2007
68 Yang, B.-G., Tanaka, T., Jang, M.H., Bai, Z., Hayasaka, H. & Miyasaka, M.: Binding of lymphoid chemokines to collagen IV that accumulates in the basal lamina of high endothelial venules; its implication in lymphocyte trafficking. J.Immunol., 179: 4376-4382, 2007. (PubMed)

67 *Matsutani, T., *Tanaka, T., Tohya, K., Otani, K., Jang, M.H., Umemoto, E., Taniguchi, K., Hayasaka, H., Ueda, K. & Miyasaka, M. (*equal contribution): Plasmacytoid dendritic cells employ multiple cell adhesion molecules sequentially to interact with high endothelial venule cells - Molecular basis of their trafficking to lymph nodes. Int.Immunol., 9:1031-1037, 2007. (PubMed)

66 Matsumoto, M., Shigeta, A., Furukawa, Y., Tanaka, T., Miyasaka, M. & Hirata, T.: CD43 collaborates with P-selectin glycoprotein ligand-1 to mediate E-selectin-dependent T cell migration into inflamed skin. J.Immunol., 178:2499-2506, 2007. (PubMed)

65 Yotsui, T., Yasuda, O., Kawamoto, H., Higuchi, M., Chihara, Y., Umemoto, E., Tanaka, T. & Miyasaka, M., Rakugi, H. & Ogihara, T.: Aspirin prevents adhesion of T lymphoblasts to vascular smooth muscle cells. FEBS Lett., 581:427-432, 2007. (PubMed)

2006

64 Watanabe, T., Masuyama, J., Sohma, Y., Inazawa, H., Horie, K., Kojima, K., Uemura, Y., Aoki, Y., Kaga, S., Minota, S., Tanaka, T., Yamaguchi, Y., Kobayashi, T. & Serizawa I.: CD52 is a novel costimulatory molecule for induction of CD4+ regulatory T cells. Clin.Immunol., 120:247-259, 2006. (PubMed)

63 Araki-Sasaki, K., Tanaka, T., Ebisuno, Y., Kanda, H., Umemoto, E., Hayashi, K. & Miyasaka, M.: Dynamic expression of chemokines and the infiltration of inflammatory cells in the HSV-infected cornea and its associated tissues. Ocul.Immunol.Inflamm., 14:257-266, 2006. (PubMed)

62 Umemoto, E., #Tanaka, T., Kanda, H., Jin, S., Tohya, K., Otani, K., Matsutani, T., Matsumoto, M., Ebisuno, Y., Jang, M.H., Fukuda, M., Hirata, T. & Miyasaka, M. (#corresponding author): Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow. J.Exp.Med., 203:1603-1614, 2006. (PubMed)

61 Sato, N., Okochi, M., Taniyama, Y., Kurinami, H., Shimamura, M., Takeuchi, D., Hamada, H., Fukumori, A., Kiyosue, K., Taguchi, T., Tanaka, T., Miyasaka, M., Takeda, M., Ogihara, T. & Morishita, R.: Development of new screening system for Alzheimer Disease, in vitro Abeta sink assay, to indentify the dissociation of soluble Aβ from fibrils. Neurobiol.Dis., 22:487-495, 2006. (PubMed)

60 *Jang, M., *Sougawa, N., Tanaka, T., Hirata, T., Hiroi, T., Tohya, K., Guo, Z., Umemoto, E., Ebisuno, Y., Yang, B., Seoh, J., Lipp, M., Kiyono, H. & Miyasaka, M. (*equal contribution) CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. J.Immunol., 176:803-810, 2006. (PubMed) Comments in J.Immunol.

2005
59 Nakai, K., #Tanaka, T., Murai, T., Ohguro, N., Tano, Y. & Miyasaka, M. (#corresponding author) Invasive human pancreatic carcinoma cells adhere to endothelial tri-cellular corners and increase endothelial permeability. Cancer Sci., 96:766-773, 2005. (PubMed)

58 *Kanemitsu, N., *Ebisuno, Y., *#Tanaka, T., Otani, K., Hayasaka, H., Kaisho, T., Akira, S., Katagiri, K., Kinashi, T., Fujita, N., Tsuruo, T. & Miyasaka, M. (*equal contribution, #corresponding author) CXCL13 is an arrest chemokine for B cells in high endothelial venules. Blood, 106:2613-2618, 2005. (PubMed)

2004
57 Kanda, H., *Tanaka, T., Matsumoto, M., Umemoto, E., Ebisuno, Y., Kinoshita, M., Noda, M., Kannagi, R., Hirata, T., Murai, T. Fukuda, M. & Miyasaka. M. (*equal contribution) Endomucin, a sialomucin expressed in high endothelial venules, supports L-selectin-mediated rolling. Int.Immunol. 16:1265-1274, 2004. (PubMed)

2003
56 *Ebisuno, Y., *Tanaka, T., Kanemitsu, N., Kanda, H., Yamaguchi, K., Kaisho, T., Akira, S. & Miyasaka, M. (*equal contribution) Cutting Edge: The B cell chemokine CXCL13/B-lymphocyte chemoattractant is expressed in the high endothelial venules of lymph nodes and Peyer’s patches and affects B cell trafficking across high endothelial venules. J.Immunol., 171:1642-1646, 2003. (PubMed)

55 Kashiwazaki, M., *Tanaka, T., Kanda, H., Ebisuno, Y., Izawa, D., Fukuma, N., Akimitsu, N., Sekimizu, K., Monden, M. & Miyasaka, M. (*equal contribution) A high endothelial venule-expressing promiscuous chemokine receptor DARC can bind the inflammatory but not lymphoid chemokines and is dispensable for lymphocyte homing under physiological conditions. Int.Immunol., 15:1219-1227, 2003. (PubMed)

54 Nagakubo, D., Murai, T., Tanaka, T., Usui, T., Matsumoto, M., Sekiguchi, K. & Miyasaka, M. A high endothelial venule secretory protein, mac25/angiomodulin, interacts with multiple high endothelial venule-associated molecules including chemokines. J.Immunol., 171:553-561, 2003. (PubMed)

53 Tanaka, T., Ebisuno, Y., Kanda, H., Umemoto, E., Nagakubo, D., Usui, T., Kashiwazaki, M., Murai, T. & Miyasaka, M. Expression of chemokines and chemokine binding molecules in high endothelial venules that mediate lymphocyte homing into lymph nodes and Peyer’s patches. Microcirculation Annual, 19:3-6, 2003. (PubMed)

52 Kabashima, K., Murata, T., Tanaka, H., Matsuoka, T., Sakata, D., Yoshida, N., Katagiri, K., Kinashi, T., Tanaka, T., Miyasaka, M., Nagai, H., Ushikubi, F. & Narumiya, S. Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity. Nature Immunol., 4:694-701, 2003. (PubMed)

2002
51 Usui, T., Murai, T., Tanaka, T., Yamaguchi, K., Nagakubo, D., Lee, C.M., Kiyomi, M., Tamura, S., Matsuzawa, Y. & Miyasaka, M. Characterization of mac25/angiomodulin (AGM) expression by high endothelial venule cells in lymphoid tissues and its identification as an inducible marker for activated endothelial cells. Int.Immunol., 14:1273-1282, 2002. (PubMed)

50 Takeuchi, E., Tanaka, T., Umemoto, E., Tomita, T., Shi, K., Takahi, K., Suzuki, R., Ochi, T. & Miyasaka, M. VLA-4-dependent and –independent pathways in cell contact-induced proinflammatory cytokine production by synovial nurse-like cells from rheumatoid arthritis patients. Arthritis Res., 4:R10, 2002. (PubMed)

49 Lee, C.M., Tanaka, T., Murai, T., Kondo, M., Kimura, J., Su, W., Kitagawa, T., Ito, T., Matsuda, H. & Miyasaka, M. Novel chondroitin sulfate-binding cationic liposomes loaded with cisplatin efficiently suppress the local growth and liver metastasis of tumor cells in vivo. Cancer Res., 62:4282-4288, 2002. (PubMed)

48 Nishioka, E., Tanaka, T., Yoshida, H., Matsumura, K., Nishikawa, S., Naito, A., Inoue, J., Funasaka, Y., Ichihashi, M., Miyasaka, M. & Nishikawa, S. Mucosal addressin cell adhesion molecule１plays an unexpected role in the development of mouse gaurd hair. J.Invest.Dermatol., 119:632-638, 2002. (PubMed)

47 Kimura, F., Gotoh, M., Tanaka, T., Luo, Z., Miyazaki, J., Monden, M., Uede, T. & Miyasaka, M. Effects of locally expressed CTLA4-Ig in a pancreatic beta cell line on the accelerated graft rejection response induced by donor-specific transfusion. Diabetologia, 45:831-840, 2002. (PubMed)

46 Murata, S., Tanaka, T. & Miyasaka, M. Lymphocyte binding to MAdCAM-1 via α4ß7 integrin activates a signal transduction pathway involving tyrosine phosphorylation of paxillin and p105Cas-L. Immunol.Letters, 81:223-228, 2002. (PubMed)

45 Saito, K., Tanaka, T., Kanda, H., Ebisuno, Y., Izawa, D., Kawamoto, S., Okubo, K. & Miyasaka, M. Gene expression profiling of mucosal addressin cell adhesion molecule-1+ high endothelial venule cells (HEV) and identification of a leucine-rich HEV glycoprotein as a HEV marker. J.Immunol., 168:1050-1059, 2002. (PubMed)

2001
44 Fujimoto, T., Kawashima, H., Tanaka, T., Hirose, M., Toyama-Sorimachi, N., Matsuzawa, Y. & Miyasaka, M. CD44 binds a chondroitin sulfate proteoglycan, aggrecan. Int.Immunol., 13:359-366, 2001. (PubMed)

2000
43 Iizuka, T., Tanaka, T., Suematsu, M., Miura, S., Watanabe, T., Koike, R., Ishimura, Y., Ishii, H., Miyasaka, N. & Miyasaka, M. Stage-specific expression of mucosal addressin cell adhesion molecule-1 during embryogenesis in rats. J.Immunol., 164: 2463-2471, 2000. (PubMed)

42 Luo, Z., Gotoh, M., Grochowiecki, T., Tanaka, T., Kimura, F., Kawashima, H., Yagita, H., Okumura, K. & Miyasaka, M. Anergic T cells generated in vitro suppress rejection response to islet allografts. Transplantation, 69:2144-2148, 2000. (PubMed)

1999
41 Izawa, D., Tanaka, T., Saito, K., Ogihara, H., Usui, T., Kawamoto, S., Matsubara, K., Okubo, K. & Miyasaka, M. Expression profile of active genes in mouse lymph node high endothelial cells. Int.Immunol., 11:1989-1997, 1999. (PubMed)

40 Kanoh, N., Dai, C-F, Tanaka, T., Izawa, D., Li, Y-F., Kawashima, H. & Miyasaka, M. Constitutive expression of GlyCAM-1 core protein in the rat cochlea. Cell Adhes.Commun., 7:259-266, 1999. (PubMed)

39 Hiraoka, N., Petryniak, B., Nakayama, J., Tsuboi, S., Suzuki, M., Yeh, J-C., Izawa, D., Tanaka, T., Miyasaka, M., Lowe, J.B. & Fukuda, M. A novel, high endothelial venule-specific sulfotransferase expresses 6-sulfo sialyl Lewisx, an L-selectin ligand displayed by CD34. Immunity, 11:79-89, 1999. (PubMed)

38 Ishii, E., Yoshida, N., Kimura, N., Fujimoto, J., Mizutani, S., Sako, M., Hibi, S., Nagano, M., Yoshida, T., Mori, T., Kiyokawa, N., Mohri, S., Tanaka, T., Miyazaki ,S. & Hara, T. Clonal dissemination of T-lymphocytes in scid mice from familial hemophagocytic lymphohistiocytosis. Med.Pediatr.Oncol., 32:201-208, 1999. (PubMed)

37 Luo, Z-J., Tanaka, T., Kimura, F. & Miyasaka, M. Analysis of the mode of action of a novel immunosuppresant FTY720 in mice. Immunopharmacology, 41:199-207, 1999. (PubMed)

36 Goda, K., Tanaka, T., Monden, M. & Miyasaka, M. Characterization of an apparently conserved epitope in E- and P-selectin identified by dual-specific monoclonal antibodies. Eur.J.Immunol., 29:1551-1560, 1999. (PubMed)

1998
35 Ohta, Y., Gotoh, M., Ohzato, H., Fukuzaki, T., Nishihara, M., Dono, K., Umeshita, K., Sakon, M., Yagita, H., Okumura, K., Tanaka, T., Kawashima, H., Miyasaka, M. & Monden, M. Direct antigen presentation through binding of donor ICAM-1 to recipient LFA-1 molecules in xenograft rejection. Transplantation, 65:1094-1100, 1998. (PubMed)

 1997
34 Aoki, J., Koike, S., Asou, H., Ise, I., Suwa, H., Tanaka, T., Miyasaka, M. & Nomoto, A. Mouse homolog of poliovirus receptor-related gene 2 product, mPRR2, mediates homophilic cell aggregation. Exp.Cell Res., 235:374-384, 1997. (PubMed)

33 Isobe, M., Suzuki, J., Okubo, Y., Horie, S., Tanaka, T., Miyasaka, M. & Sekiguchi, M. Treatment of murine cardiac allograft by monoclonal antibodies to IL-2 receptor α chain and ß chain. Transplantat.Proc., 29: 2301-2302, 1997. (PubMed)

32 Koyanagi, Y., Tanaka, Y., Kira, J., Ito, M., Hioki, K., Misawa, N., Kawano, Y., Yamasakai, K., Tanaka, R., Suzuki, Y., Ueyama, Y., Terada, E., Tanaka, T., Miyasaka, M., Kobayashi, T., Kumazawa, Y. & Yamamoto, N. Primary human immuno-dificiency virus type 1 viremia and central nervous system invasion in a novel hu-PBL-immunodificient mouse strain. J.Virol., 71:2417-2424, 1997. (PubMed)

1996
31 Miyakawa, Y., Fukuchi, Y., Ito, M., Kobayashi, K., Kuramochi, T., Ikeda, Y., Takebe ,Y., Tanaka, T., Miyasaka, M., Nakahata, T., Tamaoki, N., Nomura, T., Ueyama, Y. & Shimamura, K. Establishment of human granulocyte-macrophage colony stimulating factor producing transgenic SCID mice. Br.J.Haematol., 95:437-442, 1996. (PubMed)

30 Ehl, S., Nuesch, R., Tanaka, T., Miyasaka, M., Hengartner, H. & Zinkernagel, R. A comparison of efficacy and specificity of three NK depleteing antibodies. J.Immunol.Methods, 199:149-153, 1996. (PubMed)

29 Yano, S., Nishioka, Y., Izumi, K., Tsuruo, T., Tanaka, T., Miyasaka, M. & Sone, S. Novel metastatic model of human lung cancer in NK-cell depleted SCID mice. Int.J.Cancer, 67:211-217, 1996. (PubMed)

28 Chastagner, P., Moreau, J.L, Jacques, Y., Tanaka, T., Miyasaka, M., Kondo, M., Sugamura, K. & Theze, J. Lack of intermediate-affinity interleukin-2 receptor in mice leads to dependence on interleukin-2 receptor a, b, g chain expression for T cell growth. Eur.J.Immunol., 26:201-206, 1996. (PubMed)

1995
27 Moreau, J.L, Chastagner, P., Tanaka, T., Miyasaka, M., Kondo, M., Sugamura, K. & Theze, J. Control of the IL-2 responsiveness of B lymphocytes by IL-2 and IL-4. J.Immunol., 155:3401-3408, 1995. (PubMed)

26 Suwa, H., Tanaka, T., Kitamura, F., Shiohara ,T., Kuida, K. & Miyasaka, M. Dysregulated expression of the IL-2 receptor ß-chain abrogates development of NK cells and Thy-1+ dendritic epidermal cells in transgenic mice. Int.Immunol., 7:1441-1449, 1995. (PubMed)

25 Nakanishi, K., Yoshimoto, T., Chu, C.C., Matsumoto, H., Hase, K., Nagai, N., Tanaka, T., Miyasaka, M., Paul, W.E. & Shinka, S. IL-2 inhibits IL-4-dependent IgE and IgG1 production in vitro and in vivo. Int.Immunol., 7:259-268, 1995. (PubMed)

1994
24 Tomida, S., Hasegawa, T., Takeuchi, M., Niimi, N., Ueda, M., Kaneda, T., Tanaka, T., Tamatani, T., Miyasaka, M. & Yoshikai, Y. Intercellular adhesion molecule-1 and leukocyte function-associated antigen-1 are involved in protection mediated by CD3+TCRgd- T cells at the early stage after infection with Listeria monocytogenes in rats. Int.Immunol., 6367:955-961, 1994. (PubMed)

23 Ohtsuka, K., Iiai, T., Watanabe, H., Tanaka, T., Miyasaka, M., Sato, K., Asakura, H. & Abo, T. Similarities and differences between extrathymic T cells residing in mouse liver and intestine. Cell.Immunol., 153:52-66, 1994. (PubMed)

1993
22 Tanaka, T., Kitamura, F., Nagasaka, Y., Kuida, K., Suwa, H. & Miyasaka, M. Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor ß chain monoclonal antibody in mice. J.Exp.Med., 178:1103-1107, 1993. (PubMed)

21 Ohmori, K., Iiai, T., Watanebe, H., Tanaka, T., Miyasaka, M. & Abo, T. Activation of extrathymic T cells in the liver of mice bearing syngeneic tumors. Biomed.Res., 14:65-79, 1993. (PubMed)

20 Kondo, A., Imada, K., Hattori, T., Yamabe, H., Tanaka, T., Miyasaka, M., Okuma, M. & Uchiyama, T. A model of in vivo cell proliferation of adult T cell leukemia. Blood, 82:2501-2509, 1993. (PubMed)

19 Watanabe, H., Iiai, T., Kimura, M., Ohtsuka, K., Tanaka, T., Miyasaka, M., Tsuchida, M., Hanawa, H. & Abo T. Characterization of intermediate TCR cells in the liver of mice with respect to their unique IL-2R expression. Cell.Immunol., 149:331-342, 1993. (PubMed)

18 Tanaka, T., Nagasaka, Y., Kitamura, F., Kuida, K., Suwa, H. & Miyasaka, M. The role of the interleukin-2 (IL-2)/IL-2 receptor pathway in MRL/lpr lymphoadenopathy: the expanded CD4-8- T cell subset completely lacks functional IL-2 receptors. Eur.J.Immunol., 23:1378-1380, 1993. (PubMed)

1992
17 Hasegawa, T., Tanaka, T. & Yoshikai, Y. The appearance and role of gd T cells in the peritoneal cavity and liver during primary infection with Listeria monocytogenes in rats. Int.Immunol., 4:1129-1136, 1992. (PubMed)

16 Kuida, K., Tanaka, T., Kitamura, F., Toyama-Sorimachi, N. & Miyasaka, M. Reconstitution of the intermediate-affinity interleukin-2 receptor by cell fusion. Int.Immunol., 4:1123-1128, 1992. (PubMed)

15 Takeuchi, Y., Tanaka, T., Hamamura, K., Sugimoto, T., Miyasaka, M., Yagita, H. & Okumura, K. Expression and role of interleukin-2 receptor ß chain on CD4-8- T cell receptor ab+ cells. Eur.J.Immunol., 22:2929-2935, 1992. (PubMed)

14 Tanaka, T., Takeuchi, Y., Shiohara, T., Kitamura, F., Nagasaka, Y., Hamamura, K., Yagita, H. & Miyasaka, M. In utero treatment with monoclonal antibody to IL-2 receptor ß-chain completely abrogates development of Thy-1+ dendritic epidermal cells. Int.Immunol., 4:487-491, 1992. (PubMed)

13 Takahashi, K., Nakata, M., Tanaka, T., Adachi, H., Nakauchi, H., Yagita, H. & Okumura K. CD4 and CD8 regulate interleukin 2 responses of T cells. Proc.Natl.Acad.Sci.USA., 89:5557-5561, 1992. (PubMed)

12 Nakanishi, K., Hirose, S., Yoshimoto, T., Ishizashi, H., Hiroishi, K., Tanaka, T., Kono T., Miyasaka, M., Taniguchi, T. & Higashino. K. Role and regulation of interleukin (IL)-2 receptor a and ß chains in IL-2-driven B cell growth. Proc.Natl.Acad.Sci.USA, 89:3551-3555, 1992. (PubMed)

11 Takimoto, H., Nakamura, T., Takeuchi, M., Sumi, Y., Tanaka, T., Nomoto, K. & Yoshikai, Y. Age-associated increase in number of CD4+CD8+ intestinal intraepithelial lymphocytes in rats. Eur.J.Immunol., 22:159-164, 1992. (PubMed)

10 Shimada, S., Shibagaki, N., Tanaka, T., Kubota, Y., Hashimoto, Y. & Tamaki, K. Identification of an equivalent to murine Thy-1+ dendritic epidermal cells in the rat epidermis. J.Dermatol.Sci., 3:68-71, 1992. (PubMed)

1991
9 Tanaka, T., Tsudo, M., Karasuyama, H., Kitamura, F., Kono, T., Hatakeyama, M., Taniguchi, T. & Miyasaka, M. A novel monoclonal antibody against murine IL-2 receptor ß-chain: Characterization of receptor expression in normal lymphoid cells and EL-4 cells. J.Immunol., 147:2222-2228, 1991. (PubMed)

8 Tanaka, T., Tsudo, M., Karasuyama, H., Toyama, N., Hatakeyama, M., Taniguchi, T. & Miyasaka, M. Signal transduction through the human IL-2 receptor ß-chain expressed in IL-6-dependent mouse B cell hybridoma. Int.Immunol., 3:105-108, 1991. (PubMed)

7 Tamatani, T., Kotani, M., Tanaka, T. & Miyasaka, M. Molecular mechanisms underlying lymphocyte recirculation. II. Differential regulation of LFA-1 in the interaction between lymphocytes and high endothelial cells. Eur.J.Immunol., 21:855-858, 1991. (PubMed)

1990
6 Grace, J.A., Sarawar, S.R., Bolton, E.M., Bradley, J.A., Tanaka, T. & Bell, E.B. Renal allograft rejection in CD4+ T cell-reconstituted athymic nude rats. Transplantation, 50:996-1000, 1990. (PubMed)

5 Tsudo, M., Karasuyama, H., Kitamura, F., Tanaka, T., Kubo, S., Yamamura, Y., Tamatani, T., Hatakeyama, M., Taniguchi, T. & Miyasaka, M. The IL-2 receptor ß-chain (p70). Ligand binding ability of the cDNA-encoding membrane and secreted forms. J.Immunol., 145:599-606, 1990. (PubMed)

1989
4 Tsudo, M., Karasuyama, H., Kitamura, F., Nagasaka, Y., Tanaka, T. & Miyasaka, M. Reconstitution of a functional IL-2 receptor by the ß-chain cDNA. A newly acquired receptor transduces negative signal. J.Immunol., 143:4039-4043, 1989. (PubMed)

3 Tanaka, T., Suzuki, S., Masuko, T. & Hashimoto, Y. In vitro targeting and cytotoxicity of adriamycin in liposomes bearing monoclonal antibody against rat or human gp125 cell proliferation-associated antigen. Jpn.J.Cancer Res., 80:380-386, 1989. (PubMed)

2 Tanaka, T., Masuko, T., Yagita, H., Tamura, T. & Hashimoto, Y. Characterization of a CD3-like rat T cell surface antigen recognized by a monoclonal antibody. J.Immunol., 142:2791-2795, 1989. (PubMed)

1988
1 Tanaka, T., Masuko, T. & Hashimoto, Y. Appearance of a proliferation-associated antigen, gp125, on rat and human lymphocytes by co-stimulation with phorbol ester and calcium ionophore. J.Biochem., 103:644-649, 1988. (PubMed)