Journal Club(抄読会)

by Author NameSept 8th, 2018

「免疫学とその関連分野の最新の情報を把握すること」・「英文原著に親しむこと」を目的に、抄読会を行っています。配属の5年生は研究実習の一環として論文紹介を担当します。

2019

200204 畑
Alspach E, Lussier DM, Miceli AP, Kizhvatov I, DuPage M, Luoma AM, Meng W, Lichti CF, Esaulova E, Vomund AN, Runci D, Ward JP, Gubin MM, Medrano RFV, Arthur CD, White JM, Sheehan KCF, Chen A, Wucherpfennig KW, Jacks T, Unanue ER, Artyomov MN, Schreiber RD.
Nature. 2019 Oct;574(7780):696-701.  [PubMed]

191217-200114 赤松
Opposing Functions of Interferon Coordinate Adaptive and Benci JL, Johnson LR, Choa R, Xu Y, Qiu J, Zhou Z, Xu B, Ye D, Nathanson KL, June CH, Wherry EJ, Zhang NR, Ishwaran H, Hellmann MD, Wolchok JD, Kambayashi T, Minn AJ.
Cell. 2019 Aug 8;178(4):933-948.e14.  [PubMed]

191203 笠松
CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy.
Barkal AA, Brewer RE, Markovic M, Kowarsky M, Barkal SA, Zaro BW, Krishnan V, Hatakeyama J, Dorigo O, Barkal LJ, Weissman IL.
Nature. 2019 Aug;572(7769):392-396.  [PubMed]

191015 黒崎
A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis.
Johnson DB, McDonnell WJ, Gonzalez-Ericsson PI, Al-Rohil RN, Mobley BC, Salem JE, Wang DY, Sanchez V, Wang Y, Chastain CA, Barker K, Liang Y, Warren S, Beechem JM, Menzies AM, Tio M, Long GV, Cohen JV, Guidon AC, O'Hare M, Chandra S, Chowdhary A, Lebrun-Vignes B, Goldinger SM, Rushing EJ, Buchbinder EI, Mallal SA, Shi C, Xu Y, Moslehi JJ, Sanders ME, Sosman JA, Balko JM.
Nat Med. 2019 Aug;25(8):1243-1250.  [PubMed]

191001 大野
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance.
Verma V, Shrimali RK, Ahmad S, Dai W, Wang H, Lu S, Nandre R, Gaur P, Lopez J, Sade-Feldman M, Yizhak K, Bjorgaard SL, Flaherty KT, Wargo JA, Boland GM, Sullivan RJ, Getz G, Hammond SA, Tan M, Qi J, Wong P, Merghoub T, Wolchok J, Hacohen N, Janik JE, Mkrtichyan M, Gupta S, Khleif SN.
Nat Immunol. 2019 Sep;20(9):1231-1243.  [PubMed]

190611 北垣
Paradoxical effects of obesity on T cell function during tumor progression and PD-1checkpoint blockade.
Wang Z, Aguilar EG, Luna JI, Dunai C, Khuat LT, Le CT, Mirsoian A, Minnar CM, Stoffel KM, Sturgill IR, Grossenbacher SK, Withers SS, Rebhun RB, Hartigan-O'Connor DJ, Méndez-Lagares G, Tarantal AF, Isseroff RR, Griffith TS, Schalper KA, Merleev A, Saha A, Maverakis E, Kelly K, Aljumaily R, Ibrahimi S, Mukherjee S, Machiorlatti M, Vesely SK, Longo DL, Blazar BR, Canter RJ, Murphy WJ, Monjazeb AM.
Nat Med. 2019 Jan;25(1):141-151.  [PubMed]

190521 森本
Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell CrosstalkInvolving the Cytokines IFN-γ and IL-12.
Garris CS, Arlauckas SP, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ.
Immunity. 2018 Dec 18;49(6):1148-1161.e7. [PubMed]

190514 花澤
Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3.
Wang J, Sanmamed MF, Datar I, Su TT, Ji L, Sun J, Chen L, Chen Y, Zhu G, Yin W, Zheng L, Zhou T, Badri T, Yao S, Zhu S, Boto A, Sznol M, Melero I, Vignali DAA, Schalper K, Chen L.
Cell. 2019 Jan 10;176(1-2):334-347.e12. [PubMed]

190507 福山
Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells.
André P, Denis C, Soulas C, Bourbon-Caillet C, Lopez J, Arnoux T, Bléry M, Bonnafous C, Gauthier L, Morel A, Rossi B, Remark R, Breso V, Bonnet E, Habif G, Guia S, Lalanne AI, Hoffmann C, Lantz O, Fayette J, Boyer-Chammard A, Zerbib R, Dodion P, Ghadially H, Jure-Kunkel M, Morel Y, Herbst R, Narni-Mancinelli E, Cohen RB, Vivier E.
Cell. 2018 Dec 13;175(7):1731-1743.e13. [PubMed]

190423 上原
NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drugcombination.
Ruscetti M, Leibold J, Bott MJ, Fennell M, Kulick A, Salgado NR, Chen CC, Ho YJ, Sanchez-Rivera FJ, Feucht J, Baslan T, Tian S, Chen HA, Romesser PB, Poirier JT, Rudin CM, de Stanchina E, Manchado E, Sherr CJ, Lowe SW.
Science. 2018 Dec 21;362(6421):1416-1422. [PubMed]

190416 島田
Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade.
Ishizuka JJ, Manguso RT, Cheruiyot CK, Bi K, Panda A, Iracheta-Vellve A, Miller BC, Du PP, Yates KB, Dubrot J, Buchumenski I, Comstock DE, Brown FD, Ayer A, Kohnle IC, Pope HW, Zimmer MD, Sen DR, Lane-Reticker SK, Robitschek EJ, Griffin GK, Collins NB, Long AH, Doench JG, Kozono D, Levanon EY, Haining WN.
Nature. 2019 Jan;565(7737):43-48. [PubMed]

190409 片倉
The IL-15-AKT-XBP1s signaling pathway contributes to effector functions and survival in human NK cells.
Wang Y, Zhang Y, Yi P, Dong W, Nalin AP, Zhang J, Zhu Z, Chen L, Benson DM, Mundy-Bosse BL, Freud AG, Caligiuri MA, Yu J.
Nat Immunol. 2019 Jan;20(1):10-17. [PubMed]

2018

180703 松本
PKM1 confers metabolic advantages and promotes cell-autonomous tumor cell growth.
Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N.
Cancer Cell. 2018 Mar 12;33(3):355-367.e7. [PubMed]

180626 中村
Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells.
Burrack KS, Huggins MA, Taras E, Dougherty P, Henzler CM, Yang R, Alter S, Jeng EK, Wong HC, Felices M, Cichocki F, Miller JS, Hart GT, Johnson AJ, Jameson SC, Hamilton SE.
Immunity. 2018 Apr 17;48(4):760-772.e4. [PubMed]

180612 北角
Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1.
Li CW, Lim SO, Chung EM, Kim YS, Park AH, Yao J, Cha JH, Xia W, Chan LC, Kim T, Chang SS, Lee HH, Chou CK, Liu YL, Yeh HC, Perillo EP, Dunn AK, Kuo CW, Khoo KH, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Huang TH, Sahin AA, Hortobagyi GN, Yoo SS, Hung MC.
Cancer Cell. 2018 Feb 12;33(2):187-201.e10. [PubMed]

180529 柳田
Tumor-Repopulating Cells Induce PD-1 Expression in CD8+ T Cells by Transferring Kynurenine and AhR Activation.
Liu Y, Liang X, Dong W, Fang Y, Lv J, Zhang T, Fiskesund R, Xie J, Liu J, Yin X, Jin X, Chen D, Tang K, Ma J, Zhang H, Yu J, Yan J, Liang H, Mo S, Cheng F, Zhou Y, Zhang H, Wang J, Li J, Chen Y, Cui B, Hu ZW, Cao X, Xiao-Feng Qin F, Huang B.
Cancer Cell. 2018 Mar 12;33(3):480-494.e7. [PubMed]

180522 真鍋
NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis.
Glasner A, Levi A, Enk J, Isaacson B, Viukov S, Orlanski S, Scope A, Neuman T, Enk CD, Hanna JH, Sexl V, Jonjic S, Seliger B, Zitvogel L, Mandelboim O.
Immunity. 2018 Jan 16;48(1):107-119.e4. [PubMed]

180515 岸本
Dysregulated IL-18 is a key driver of immunosuppression and a possible therapeutic target in the multiple myeloma microenvironment.
Nakamura K, Kassem S, Cleynen A, Chrétien ML, Guillerey C, Putz EM, Bald T, Förster I, Vuckovic S, Hill GR, Masters SL, Chesi M, Bergsagel PL, Avet-Loiseau H, Martinet L, Smyth MJ.
Cancer Cell. 2018 Apr 9;33(4):634-648.e5. [PubMed]

180508 大野
Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice
Brown M, Assen FP, Leithner A, Abe J, Schachner H, Asfour G, Bago-Horvath Z, Stein JV, Uhrin P, Sixt M, Kerjaschki D.
Science. 2018 Mar 23;359(6382):1408-1411. [PubMed]

2017

180206 西村
CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.
Burr ML, Sparbier CE, Chan YC, Williamson JC, Woods K, Beavis PA, Lam EYN, Henderson MA, Bell CC, Stolzenburg S, Gilan O, Bloor S, Noori T, Morgens DW, Bassik MC, Neeson PJ, Behren A, Darcy PK, Dawson SJ, Voskoboinik I, Trapani JA, Cebon J, Lehner PJ, Dawson MA.
Nature. 2017 Sep 7;549(7670):101-105. [PubMed]

180130 有本
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade.
Wei SC, Levine JH, Cogdill AP, Zhao Y, Anang NAS, Andrews MC, Sharma P, Wang J, Wargo JA, Pe'er D, Allison JP.
Cell. 2017 Sep 7;170(6):1120-1133.e17. [PubMed]

180123 西川
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.
Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, Fidelle M, Flament C, Poirier-Colame V, Opolon P, Klein C, Iribarren K, Mondragón L, Jacquelot N, Qu B, Ferrere G, Clémenson C, Mezquita L, Masip JR, Naltet C, Brosseau S, Kaderbhai C, Richard C, Rizvi H, Levenez F, Galleron N, Quinquis B, Pons N, Ryffel B, Minard-Colin V, Gonin P, Soria JC, Deutsch E, Loriot Y, Ghiringhelli F, Zalcman G, Goldwasser F, Escudier B, Hellmann MD, Eggermont A, Raoult D, Albiges L, Kroemer G, Zitvogel L.
Science. 2018 Jan 5;359(6371):91-97. [PubMed]

180116 大野
Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth.
Germano G, Lamba S, Rospo G, Barault L, Magrì A, Maione F, Russo M, Crisafulli G, Bartolini A, Lerda G, Siravegna G, Mussolin B, Frapolli R, Montone M, Morano F, de Braud F, Amirouchene-Angelozzi N, Marsoni S, D'Incalci M, Orlandi A, Giraudo E, Sartore-Bianchi A, Siena S, Pietrantonio F, Di Nicolantonio F, Bardelli A.
Nature. 2017 Dec 7;552(7683):116-120.  [PubMed]

170711 二宮
Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent.
Kamphorst AO, Wieland A, Nasti T, Yang S, Zhang R, Barber DL, Konieczny BT, Daugherty CZ, Koenig L, Yu K, Sica GL, Sharpe AH, Freeman GJ, Blazar BR, Turka LA, Owonikoko TK, Pillai RN, Ramalingam SS, Araki K, Ahmed R.
Science. 2017 Mar 31;355(6332):1423-1427.  [PubMed]

170704 加戸
Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer.
Sanja Stevanović,  Anna Pasetto, Sarah R. Helman, Jared J. Gartner, Todd D. Prickett, Bryan Howie, Harlan S. Robins, Paul F. Robbins, Christopher A. Klebanoff, Steven A. Rosenberg, Christian S. Hinrichs.
Science. 2017 Apr 14;356(6334):200-205.  [PubMed]

170627 大野
Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells.
Mendoza A, Fang V, Chen C, Serasinghe M, Verma A, Muller J, Chaluvadi VS, Dustin ML, Hla T, Elemento O, Chipuk JE, Schwab SR.
Nature. 2017 Jun 1;546(7656):158-161. [PubMed]

170530 河野
Modulating the therapeutic response of tumours to dietary serine and glycine starvation.
Maddocks ODK, Athineos D, Cheung EC, Lee P, Zhang T, van den Broek NJF, Mackay GM, Labuschagne CF, Gay D, Kruiswijk F, Blagih J, Vincent DF, Campbell KJ, Ceteci F, Sansom OJ, Blyth K, Vousden KH.
Nature. 2017 Apr 19;544(7650):372-376. [PubMed]

170523 池谷
T-cell invigoration to tumour burden ratio associated with anti-PD-1 response
Huang AC, Postow MA, Orlowski RJ, Mick R, Bengsch B, Manne S, Xu W, Harmon S, Giles JR, Wenz B, Adamow M, Kuk D, Panageas KS, Carrera C, Wong P, Quagliarello F, Wubbenhorst B, D'Andrea K, Pauken KE, Herati RS, Staupe RP, Schenkel JM, McGettigan S, Kothari S, George SM, Vonderheide RH, Amaravadi RK, Karakousis GC, Schuchter LM, Xu X, Nathanson KL, Wolchok JD, Gangadhar TC, Wherry EJ.
Nature. 2017 May 4;545(7652):60-65.  [PubMed]

170516 大野
Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy.
Spranger S, Dai D, Horton B, Gajewski TF
Cancer Cell. 2017 May 8;31(5):711-723.e4. [PubMed]

2016

170321 内田
Targeting metastasis-initiating cells through the fatty acid receptor CD36.
Pascual G, Avgustinova A, Mejetta S, Martín M, Castellanos A, Attolini CS, Berenguer A, Prats N, Toll A, Hueto JA, Bescós C, Di Croce L, Benitah SA.
Nature. 2017 Jan 5;541(7635):41-45. [PubMed]

170314 久世
Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells
Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Moller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T.
Nat Immunol. 2017 Jan;18(1):74-85. [PubMed]

170307 森
Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs.
Gil-Cruz C, Perez-Shibayama C, Onder L, Chai Q, Cupovic J, Cheng HW, Novkovic M, Lang PA, Geuking MB, McCoy KD, Abe S, Cui G, Ikuta K, Scandella E, Ludewig B.
Nat Immunol. 2016 Dec;17(12):1388-1396. [PubMed]

170228 藤末
Evidence of innate lymphoid cell redundancy in humans.
Vély F, Barlogis V, Vallentin B, Neven B, Piperoglou C, Ebbo M, Perchet T, Petit M, Yessaad N, Touzot F, Bruneau J, Mahlaoui N, Zucchini N, Farnarier C, Michel G, Moshous D, Blanche S, Dujardin A, Spits H, Distler JH, Ramming A, Picard C, Golub R, Fischer A, Vivier E.
Nat Immunol. 2016 Nov;17(11):1291-1299.  [PubMed]

170221 中川
Loss of IFN-g Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy.
Jianjun G, Lewis Z S, Hao Z, Jianfeng C, Liangwen X, Qiuming H, Tenghui C, Jason R, Chantale B, Scott E. W, Pei-Ling C, Patrick H, James P. A, Andrew F, Jennifer A. W, and Padmanee S.
Cell. 2016 Oct 6;167(2):397-404.e9.  [PubMed]

170214 橙木
Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells.
De Henau, Rausch M, Winkler D, Campesato LF, Liu C, Cymerman DH, Budhu S, Ghosh A, Pink M, Tchaicha J, Douglas M, Tibbitts T, Sharma S, Proctor J, Kosmider N, White K, Stern H, Soglia J, Adams J, Palombella VJ, McGovern K, Kutok JL, Wolchok JD, Merghoub T.
Nature. 2016 Nov 17;539(7629):443-447. [PubMed]

170207 橋口
Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection.
He R, Hou S, Liu C, Zhang A, Bai Q, Han M, Yang Y, Wei G, Shen T, Yang X, Xu L, Chen X, Hao Y, Wang P, Zhu C, Ou J, Liang H, Ni T, Zhang X, Zhou X, Deng K, Chen Y, Luo Y, Xu J, Qi H, Wu Y, Ye L.
Nature. 2016 Aug 2;537(7620):412-428. [PubMed]

170131 長田
Defining CD8+ Tcells that provide the proliferative burst after PD-1 therapy.
Im SJ, Hashimoto M, Gerner MY, Lee J, Lissick HT, Burger MC, Shan Q, Hale JS, Lee J, Nasti TH, Sharpe AH, Freeman GJ, Germain RN, Nakaya HI, Xue HH, Ahmed R
Nature. 2016 Sep 15;537(7620):417-421. [PubMed]

170124 大野
Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion.
Bengsch B, Johnson AL, Kurachi M, Odorizzi PM, Pauken KE, Attanasio J, Stelekati E, McLane LM, Paley MA, Delgoffe GM, Wherry EJ.
Immunity. 2016 Aug 16;45(2):358-73. [PubMed]

170117 田中
Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade.
Benci JL, Xu B, Qiu Y, Wu TJ, Dada H, Twyman-Saint Victor C, Cucolo L, Lee DS, Pauken KE, Huang AC, Gangadhar TC, Amaravadi RK, Schuchter LM, Feldman MD, Ishwaran H, Vonderheide RH, Maity A, Wherry EJ, Minn AJ.
Cell. 2016 Dec 1;167(6):1540-1554.e12. [PubMed]

160707 檜垣
Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade.
Haidong Tang, Yang Wang, Lukasz K. Chlewicki, Yuan Zhang, Jingya Guo, Wei Liang, Jieyi Wang, Xiaoxiao Wang, and Yang-Xin Fu.
Cancer Cell. 2016 Mar 14;29(3):285-96. [PubMed]

160607 大野
MYC regulates the antitumor immune response through CD47 and PD-L1.
Casey SC, Tong L, Li Y, Do R, Walz S, Fitzgerald KN, Gouw AM, Baylot V, Gütgemann I, Eilers M, Felsher DW.
Science. 2016 Apr 8;352(6282):227-31. [PubMed]

160531 田中
Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer.
Wang W, Kryczek I, Dostál L, Lin H, Tan L, Zhao L, Lu F, Wei S, Maj T, Peng D, He G, Vatan L, Szeliga W, Kuick R, Kotarski J, Tarkowski R, Dou Y, Rattan R, Munkarah A, Liu JR, Zou W.
Cell. 2016 May 19;165(5):1092-105.  [PubMed]

160517 大野
Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism.
Yang W, Bai Y, Xiong Y, Zhang J, Chen S, Zheng X, Meng X, Li L, Wang J, Xu C, Yan C, Wang L, Chang CC, Chang TY, Zhang T, Zhou P, Song BL, Liu W, Sun SC, Liu X, Li BL, Xu C.
Nature. 2016 Mar 31;531(7596):651-5.  [PubMed]

160510 田中
Normalizing the environment recapitulates adult human immune traits in laboratory mice.
Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casey KA, Thompson EA, Fraser KA, Rosato PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining WN, Jameson SC, Masopust D.
Nature. 2016 Apr 28;532(7600):512-6.  [PubMed]

2015

160308 大野
Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.
Taylor A, Harker JA, Chanthong K, Stevenson PG, Zuniga EI, Rudd CE.
Immunity. 2016 Feb 16;44(2):274-86. [PubMed]

160301 田中
Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy.
Pfirschke C, Engblom C, Rickelt S, Cortez-Retamozo V, Garris C, Pucci F, Yamazaki T, Poirier-Colame V, Newton A, Redouane Y, Lin YJ, Wojtkiewicz G, Iwamoto Y, Mino-Kenudson M, Huynh TG, Hynes RO, Freeman GJ, Kroemer G, Zitvogel L, Weissleder R, Pittet MJ.
Immunity. 2016 Feb 16;44(2):343-54. [PubMed]

160223 南谷
Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver. 
Rau M, Schilling AK, Meertens J, Hering I, Weiss J, Jurowich C, Kudlich T, Hermanns HM, Bantel H, Beyersdorf N, Geier A.
J Immunol. 2016 Jan 1;196(1):97-105.  [PubMed]

160216 岩倉
Neutrophils support lung colonization of metastasis-initiating breast cancer cells
Wculek SK, Malanchi I.
Nature.2015 Dec 17;528(7582):413-417. [PubMed]

160209 前田
Tumour exosome integrins determine organotropic metastasis.
Hoshino A, Costa-Silva B, et al.
Nature. 2015 Nov 19;527(7578):329-335.  [PubMed]

160202 大野
IL-36g Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses.
Wang X, Lu B, et al.
Cancer Cell. 2015 Sep 14;28(3):296-306.  [PubMed]

160126 田中
Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis.
Nowarski R, Jackson R, Gagliani N, de Zoete MR, Palm NW, Bailis W, Low JS, Harman CC, Graham M, Elinav E, Flavell RA.
Cell. 2015 Dec 3;163(6):1444-1456.  [PubMed]

160119 大野 
ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis.
Cubillos-Ruiz JR, Silberman PC, Rutkowski MR, Chopra S, Perales-Puchalt A, Song M, Zhang S, Bettigole SE, Gupta D, Holcomb K, Ellenson LH, Caputo T, Lee AH, Conejo-Garcia JR, Glimcher LH.
Cell. 2015 Jun 18;161(7):1527-1538.  [PubMed]

1507014 板垣
Cigarette smoke silences innate lymphoid cell function and facilitates an exacerbated type I interleukin-33-dependent response to infection.
Kearley J, Silver JS, Sanden C, Liu Z, Berlin AA, White N, Mori M, Pham TH, Ward CK, Criner GJ, Marchetti N, Mustelin T, Erjefalt JS, Kolbeck R, Humbles AA.
Immunity. 2015 Mar 17;42(3):566-79. [PubMed]

150630 田上
VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors.
Voron T, Colussi O, Marcheteau E, Pernot S, Nizard M, Pointet AL, Latreche S, Bergaya S, Benhamouda N, Tanchot C, Stockmann C, Combe P, Berger A, Zinzindohoue F, Yagita H, Tartour E, Taieb J, Terme M.
J Exp Med. 2015 Feb 9;212(2):139-48.  [PubMed]

150623 藤本
A lactate-induced response to hypoxia.
Lee DC, Sohn HA, Park ZY, Oh S, Kang YK, Lee KM, Kang M, Jang YJ, Yang SJ, Hong YK, Noh H, Kim JA, Kim DJ, Bae KH, Kim DM, Chung SJ, Yoo HS, Yu DY, Park KC, Yeom YI.
Cell. 2015 Apr 23;161(3):595-609.  [PubMed]

150602 稲継
Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection.
Muñoz M, Eidenschenk C, Ota N, Wong K, Lohmann U, Kühl AA, Wang X, Manzanillo P, Li Y, Rutz S, Zheng Y, Diehl L, Kayagaki N, van Lookeren-Campagne M, Liesenfeld O, Heimesaat M, Ouyang W.
Immunity. 2015 Feb 17;42(2):321-31. [PubMed]

150526 山本
Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy.
Shalapour S, Font-Burgada J, Di Caro G, Zhong Z, Sanchez-Lopez E, Dhar D, Willimsky G, Ammirante M, Strasner A, Hansel DE, Jamieson C, Kane CJ, Klatte T, Birner P, Kenner L, Karin M.
Nature. 2015 May 7;521(7550):94-8.  [PubMed]

150519 吉原
IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis.
Coffelt SB, Kersten K, Doornebal CW, Weiden J, Vrijland K, Hau CS, Verstegen NJ, Ciampricotti M, Hawinkels LJ, Jonkers J, de Visser KE.
Nature. 2015 Mar 30. [Epub ahead of print]  [PubMed]

150512 大野
Ferroptosis as a p53-mediated activity during tumour suppression.
Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, Baer R, Gu W. 
Nature. 2015 Apr 2;520(7545):57-62.  [PubMed]

150421 田中
PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer.
Bonavita E, Gentile S, Rubino M, Maina V, Papait R, Kunderfranco P, Greco C, Feruglio F, Molgora M, Laface I, Tartari S, Doni A, Pasqualini F, Barbati E, Basso G, Galdiero MR, Nebuloni M, Roncalli M, Colombo P, Laghi L, Lambris JD, Jaillon S, Garlanda C, Mantovani A.
Cell. 2015 Feb 12;160(4):700-14.  [PubMed]

2014

150224 大野
Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells.
Ruffell B, Chang-Strachan D, Chan V, Rosenbusch A, Ho CM, Pryer N, Daniel D, Hwang ES, Rugo HS, Coussens LM.
Cancer Cell. 2014 Nov 10;26(5):623-37. [PubMed]

150217 田中
Genetic basis for clinical response to CTLA-4 blockade in melanoma.
Snyder A, Makarov V, Merghoub T, Yuan J, Zaretsky JM, Desrichard A, Walsh LA, Postow MA, Wong P, Ho TS, Hollmann TJ, Bruggeman C, Kannan K, Li Y, Elipenahli C, Liu C, Harbison CT, Wang L, Ribas A, Wolchok JD, Chan TA.
N Engl J Med. 2014; 371:2189-99. [PubMed]

150210 平
VISTA is an immune checkpoint molecule for human T cells.
Lines JL, Pantazi E, Mak J, Sempere LF, Wang L, O'Connell S, Ceeraz S, Suriawinata AA, Yan S, Ernstoff MS, Noelle R.
Cancer Res. 2014 Apr 1;74(7):1924-32. [PubMed]

150203 上田晴可
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens.
Gubin MM, Zhang X, Schuster H, Caron E, Ward JP, Noguchi T, Ivanova Y, Hundal J, Arthur CD, Krebber WJ, Mulder GE, Toebes M, Vesely MD, Lam SS, Korman AJ, Allison JP, Freeman GJ, Sharpe AH, Pearce EL, Schumacher TN, Aebersold R, Rammensee HG, Melief CJ, Mardis ER, Gillanders WE, Artyomov MN, Schreiber RD.
Nature. 2014 Nov 27;515(7528):577-81. [PubMed]

150127 山脇
Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis.
Bonapace L, Coissieux MM, Wyckoff J, Mertz KD, Varga Z, Junt T, Bentires-Alj M.
Nature. 2014 Nov 6;515(7525):130-3. [PubMed]

150120 松井
Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer.
Di Mitri D, Toso A, Chen JJ, Sarti M, Pinton S, Jost TR, D'Antuono R, Montani E, Garcia-Escudero R, Guccini I, Da Silva-Alvarez S, Collado M, Eisenberger M, Zhang Z, Catapano C, Grassi F, Alimonti A.
Nature. 2014 Nov 6;515(7525):134-7. [PubMed]

150113 高濱
PD-1 blockade induces responses by inhibiting adaptive immune resistance.
Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJ, Robert L, Chmielowski B, Spasic M, Henry G, Ciobanu V, West AN, Carmona M, Kivork C, Seja E, Cherry G, Gutierrez AJ, Grogan TR, Mateus C, Tomasic G, Glaspy JA, Emerson RO, Robins H, Pierce RH, Elashoff DA, Robert C, Ribas A.
Nature. 2014 Nov 27;515(7528):568-71. [PubMed]

140729 大野
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.
Colegio OR, Medzhitov R., et al
Nature. 2014 Sep 25;513(7519):559-63. [PubMed]

140715 田中
Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy.
Ries CH et al.
Cancer Cell. 2014 Jun 16;25(6):846-59. [PubMed]

140708 大野
A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis.
Su S, Liu Q, Chen J, Chen J, Chen F, He C, Huang D, Wu W, Lin L, Huang W, Zhang J, Cui X, Zheng F, Li H, Yao H, Su F, Song E.
Cancer Cell. 2014 May 12;25(5):605-20. [PubMed]

140702 田中
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.
Ozdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A,Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R.
Cancer Cell. 2014 Jun 16;25(6):719-34. [PubMed]

140624  岡地
Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance.
Wong CH, Jenne CN, Petri B, Chrobok NL, Kubes P.
Nat Immunol. 2013 Aug;14(8):785-92. [PubMed]

140617 松浦
Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population.
Laoui D, Van Overmeire E, Di Conza G, Aldeni C, Keirsse J, Morias Y, Movahedi K, Houbracken I, Schouppe E, Elkrim Y, Karroum O, Jordan B, Carmeliet P, Gysemans C, De Baetselier P, Mazzone M, Van Ginderachter JA.
Cancer Res. 2014 Jan 1;74(1):24-30.  [PubMed]

140610 寺田
Context-dependent activation of Wnt signaling by tumor suppressor RUNX3 in gastric cancer cells.
Ju X, Ishikawa TO, Naka K, Ito K, Ito Y, Oshima M.
Cancer Sci. 2014 Apr;105(4):418-24.  [PubMed]

140415 田中
Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium.
Schiwon M, Weisheit C, Franken L, Gutweiler S, Dixit A, Meyer-Schwesinger C, Pohl JM, Maurice NJ, Thiebes S, Lorenz K, Quast T, Fuhrmann M6,Baumgarten G, Lohse MJ, Opdenakker G, Bernhagen J, Bucala R, Panzer U, Kolanus W, Gröne HJ, Garbi N, Kastenmüller W, Knolle PA, Kurts C, Engel DR.
Cell. 2014 Jan 30;156(3):456-68.  [PubMed]

2013

140318 宮井
Activation of the FGFR-STAT3 pathway in breast cancer cells induces a hyaluronan-rich microenvironment that licenses tumor formation.
Bohrer LR, Chuntova P, Bade LK, Beadnell TC, Leon RP, Brady NJ, Ryu Y, Goldberg JE, Schmechel SC, Koopmeiners JS, McCarthy JB, Schwertfeger KL.
Cancer Res. 2014 Jan 1;74(1):374-86.  [PubMed]

140304 大島、阪井
Obesity Promotes Brest Cancer by CCL2 Mediated Macrophage Recruitment and Angiogenesis.
Arendt LM, McCready J, Keller PJ, Baker DD, Naber SP, Seewaldt V, Kuperwasser C.
Cancer Res. 2013 Oct 1;73(19):6080-93.  [PubMed]

140218 田井、高
TGF-β modulates ovarian cancer invasion by upregulating CAF-derived versican in the tumor microenvironment.
Yeung TL, Leung CS, Wong KK, Samimi G, Thompson MS, Liu J, Zaid TM, Ghosh S, Birrer MJ, Mok SC.
Cancer Res. 2013 Aug 15;73(16):5016-28.   [PubMed]

140203 大野
Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment.
Iida N, Dzutsev A, Stewart CA, Smith L, Bouladoux N, Weingarten RA, Molina DA, Salcedo R, Back T, Cramer S, Dai RM, Kiu H, Cardone M, Naik S, Patri AK,Wang E, Marincola FM, Frank KM, Belkaid Y, Trinchieri G, Goldszmid RS.
Science. 2013 Nov 22;342(6161):967-70.   [PubMed]

140128 上田
Muc5b required for airway defense. 
Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, Sisson JH, Woodruff PG, Thornton DJ, Rousseau K, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, O'Neal WK, Flores SC, Cota-Gomez A, Lozupone CA, Donnelly JM, Watson AM, Hennessy CE, Keith RC, Yang IV, Barthel L, Henson PM, Janssen WJ, Schwartz DA, Boucher RC, Dickey BF, Evans CM.
Nature. 2014 Jan 16;505(7483):412-6.  [PubMed]

140121 田中
Nivolumab plus ipilimumab in advanced melanoma.
Wolchok JD, Kluger H, Callahan MK, Postow MA, Rizvi NA, Lesokhin AM, Segal NH, Ariyan CE, Gordon RA, Reed K, Burke MM, Caldwell A, Kronenberg SA,Agunwamba BU, Zhang X, Lowy I, Inzunza HD, Feely W, Horak CE, Hong Q, Korman AJ, Wigginton JM, Gupta A, Sznol M.
N Engl J Med. 2013 Jul 11;369(2):122-33.  [PubMed]

130730 大野
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome.
Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, Oyadomari S, Iwakura Y, Oshima K, Morita H, Hattori M, Honda K, Ishikawa Y, Hara E, Ohtani N.
Nature. 2013 Jul 4;499(7456):97-101.  [PubMed]

130723 田中
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice.
Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, Li P, Olefsky JM, Saltiel AR.
Nat Med. 2013 Mar;19(3):313-21. [PubMed]

130716 清水、吉藤
Cancer Stem-like Cell Marker CD44 Promotes Bone Metastases by Enhancing Tumorigenicity, Cell Motility, and Hyaluronan Production.
Hiraga T, Ito S, Nakamura H.
Cancer Res. 2013 Jul 1;73(13):4112-22. [PubMed]

130709 秋田
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues.
Bernink JH, Peters CP, Munneke M, te Velde AA, Meijer SL, Weijer K, Hreggvidsdottir HS, Heinsbroek SE, Legrand N, Buskens CJ, Bemelman WA, Mjösberg JM, Spits H.
Nat Immunol. 2013 Mar;14(3):221-9. [PubMed]

130702 大野
High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat.
Tian X, Azpurua J, Hine C, Vaidya A, Myakishev-Rempel M, Ablaeva J, Mao Z, Nevo E, Gorbunova V, Seluanov A.
Nature. 2013 Jun 19. doi: 10.1038/nature12234. [Epub ahead of print]  [PubMed]

130618 上田
The TLR4 antagonist Eritoran protects mice from lethal influenza infection.
Shirey KA, Lai W, Scott AJ, Lipsky M, Mistry P, Pletneva LM, Karp CL, McAlees J, Gioannini TL, Weiss J, Chen WH, Ernst RK, Rossignol DP, Gusovsky F,
Blanco JC, Vogel SN.
Nature. 2013 May 23;497(7450):498-502.  [PubMed]

130611 田中
Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages.
Satoh T, Kidoya H, Naito H, Yamamoto M, Takemura N, Nakagawa K, Yoshioka Y, Morii E, Takakura N, Takeuchi O, Akira S.
Nature. 2013 Mar 28;495(7442):524-8.  [PubMed]

130604 大野
Hijacking the neuronal NMDAR signaling circuit to promote tumor growth and invasion.
Li L, Hanahan D.
Cell. 2013 Mar 28;153(1):86-100.  [PubMed]

130528 上田
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN, Hafler DA.
Nature. 2013 Apr 25;496(7446):518-22. [PubMed]

130426 田中佐弥、石原
Cutting Edge: regulation of intestinal inflammation and barrier function by IL-17C.
Reynolds JM, Martinez GJ, Nallaparaju KC, Chang SH, Wang YH, Dong C.
J Immunol. 2012 Nov 1;189(9):4226-30. [PubMed]

130423 森、田崎
Ameliorated ConA-induced hepatitis in the absence of PKC-theta.
Fang X, Wang R, Ma J, Ding Y, Shang W, Sun Z.
PLoS One. 2012;7(2):e31174. [PubMed]

130419 筆坂、瀬戸
Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses.
Mitchem JB, Brennan DJ, Knolhoff BL, Belt BA, Zhu Y, Sanford DE, Belaygorod L, Carpenter D, Collins L, Piwnica-Worms D, Hewitt S, Udupi GM, Gallagher WM, Wegner C, West BL, Wang-Gillam A, Goedegebuure P, Linehan DC, DeNardo DG.
Cancer Res. 2013 Feb 1;73(3):1128-41. [PubMed]

130419 牛尾・北山
Prostate cancer stem-like cells⁄cancer-initiating cells have an autocrine system of hepatocyte growth factor.
Nishida S, Hirohashi Y, Torigoe T, Inoue R, Kitamura H, Tanaka T, Takahashi A, Asanuma H, Masumori N, Tsukamoto T, Sato N.
Cancer Sci. 2013 Apr;104(4):431-6. [PubMed]

130415 吉田・田中亜弥  
CD40-mediated activation of chronic lymphocytic leukemia cells promotes their CD44-dependent adhesion to hyaluronan and restricts CCl21-induced motility.
Girbl T, Hinterseer E, Grössinger EM, Asslaber D, Oberascher K, Weiss L, Hauser-Kronberger C, Neureiter D, Kerschbaum H, Naor D, Alon R, Greil R,Hartmann TN.
Cancer Res. 2013 Jan 15;73(2):561-70. [PubMed]

2012

130319 田中
Persistent antigen at vaccination sites induces tumor-specific CD8+ T cell sequestration, dysfunction and deletion.
Hailemichael Y, Dai Z, Jaffarzad N, Ye Y, Medina MA, Huang XF, Dorta-Estremera SM, Greeley NR, Nitti G, Peng W, Liu C, Lou Y, Wang Z, Ma W, Rabinovich B,Schluns KS, Davis RE, Hwu P, Overwijk WW.
Nat Med. 2013 Apr;19(4):465-72. [PubMed]

130312 大野
Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor.
Zaiss DM, van Loosdregt J, Gorlani A, Bekker CP, Gröne A, Sibilia M, van Bergen En Henegouwen PM, Roovers RC, Coffer PJ, Sijts AJ.
Immunity. 2013 Feb 21;38(2):275-84. [PubMed]

130305 上田
Angiotensin II drives the production of tumor-promoting macrophages.
Cortez-Retamozo V, Etzrodt M, Newton A, Ryan R, Pucci F, Sio SW, Kuswanto W, Rauch PJ, Chudnovskiy A, Iwamoto Y, Kohler R, Marinelli B, Gorbatov R, Wojtkiewicz G, Panizzi P, Mino-Kenudson M, Forghani R, Figueiredo JL, Chen JW, Xavier R, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ.
Immunity. 2013 Feb 21;38(2):296-308. [PubMed]

130219 田中
T-helper-1-cell cytokines drive cancer into senescence.
Braumüller H, Wieder T, Brenner E, Aßmann S, Hahn M, Alkhaled M, Schilbach K, Essmann F, Kneilling M, Griessinger C, Ranta F, Ullrich S, Mocikat R,Braungart K, Mehra T, Fehrenbacher B, Berdel J, Niessner H, Meier F, van den Broek M, Häring HU, Handgretinger R, Quintanilla-Martinez L, Fend F, Pesic M,Bauer J, Zender L, Schaller M, Schulze-Osthoff K, Röcken M.
Nature. 2013 Feb 21;494(7437):361-5. [PubMed]

130205 大野
Preactivation of human MSCs with TNF-α enhances tumor-suppressive activity.
Lee RH, Yoon N, Reneau JC, Prockop DJ.
Cell Stem Cell. 2012 Dec 7;11(6):825-35. [PubMed]

130122 上田
Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production.
Lynch L, Nowak M, Varghese B, Clark J, Hogan AE, Toxavidis V, Balk SP, O'Shea D, O'Farrelly C, Exley MA.
Immunity. 2012 Sep 21;37(3):574-87. [PubMed]

130115 田中
Regeneration of Human Tumor Antigen-Specific T Cells from iPSCs Derived from Mature CD8(+) T Cells.
Vizcardo R, Masuda K, Yamada D, Ikawa T, Shimizu K, Fujii S, Koseki H, Kawamoto H.
Cell Stem Cell. 2013 Jan 3;12(1):31-6. [PubMed]

120724 三浦
TLR5, a Novel and Unidentified Inflammatory Mediator in Rheumatoid Arthritis that Correlates with Disease Activity Score and Joint TNF-α Levels.
Chamberlain ND, Vila OM, Volin MV, Volkov S, Pope RM, Swedler W, Mandelin AM 2nd, Shahrara S.
J Immunol. 2012 Jul 1;189(1):475-83. [PubMed]

120710 岡田
Fyn Promotes Th17 Differentiation by Regulating the Kinetics of RORγt and Foxp3 Expression.
Ueda A, Zhou L, Stein PL.
J Immunol. 2012 Jun 1;188(11):5247-56. [PubMed]

120703 新玉、三宅
Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction ofbreast cancer stem-like cells with macrophages and stromal cells.
Okuda H, Kobayashi A, Xia B, Watabe M, Pai SK, Hirota S, Xing F, Liu W, Pandey PR, Fukuda K, Modur V, Ghosh A, Wilber A, Watabe K.
Cancer Res. 2012 Jan 15;72(2):537-47. [PubMed]

120619 田中
Complement c1q activates canonical wnt signaling and promotes aging-related phenotypes.
Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T,Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I.
Cell. 2012 Jun 8;149(6):1298-313. [PubMed]

120612 大野
The PSA(-/lo) Prostate Cancer Cell Population Harbors Self-Renewing Long-Term Tumor-Propagating Cells that Resist Castration.
Qin J, Liu X, Laffin B, Chen X, Choy G, Jeter CR, Calhoun-Davis T, Li H, Palapattu GS, Pang S, Lin K, Huang J, Ivanov I, Li W, Suraneni MV, Tang DG.
Cell Stem Cell. 2012 May 4;10(5):556-69. [PubMed]

120605 上田
Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes.
Brennan AJ, Chia J, Browne KA, Ciccone A, Ellis S, Lopez JA, Susanto O, Verschoor S, Yagita H, Whisstock JC, Trapani JA, Voskoboinik I.
Immunity. 2011 Jun 24;34(6):879-92. [PubMed]

120529 田中
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma.
Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR.
Cancer Cell. 2012 Mar 20;21(3):418-29. [PubMed]

120522 大野
Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.
Lonardo E, Hermann PC, Mueller MT, Huber S, Balic A, Miranda-Lorenzo I, Zagorac S, Alcala S, Rodriguez-Arabaolaza I, Ramirez JC, Torres-Ruíz R, Garcia E, Hidalgo M, Cebrián DÁ, Heuchel R, Löhr M, Berger F, Bartenstein P, Aicher A, Heeschen C.
Cell Stem Cell. 2011 Nov 4;9(5):433-46. [PubMed]

120515 上田
Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation.
Jenq RR, Ubeda C, Taur Y, Menezes CC, Khanin R, Dudakov JA, Liu C, West ML, Singer NV, Equinda MJ, Gobourne A, Lipuma L, Young LF, Smith OM, Ghosh A, Hanash AM, Goldberg JD, Aoyama K, Blazar BR, Pamer EG, van den Brink MR.
J Exp Med. 2012 May 7;209(5):903-11. [PubMed]

120508 田中
Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier.
Arima Y, Harada M, Kamimura D, Park JH, Kawano F, Yull FE, Kawamoto T, Iwakura Y, Betz UA, Márquez G, Blackwell TS, Ohira Y, Hirano T, Murakami M.
Cell. 2012 Feb 3;148(3):447-57. [PubMed]

120424 秋田
Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome.
Gringhuis SI, Kaptein TM, Wevers BA, Theelen B, van der Vlist M, Boekhout T, Geijtenbeek TB.
Nat Immunol. 2012 Jan 22;13(3):246-54. [PubMed]

120417 大野
Interactions between cancer stem cells and their niche govern metastatic colonization.
Malanchi I, Santamaria-Martínez A, Susanto E, Peng H, Lehr HA, Delaloye JF, Huelsken J.
Nature. 2011 Dec 7;481(7379):85-9. [PubMed]

2011

120306 上田
Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut.
Fritz JH, Rojas OL, Simard N, McCarthy DD, Hapfelmeier S, Rubino S, Robertson SJ, Larijani M, Gosselin J, Ivanov II, Martin A, Casellas R, Philpott DJ, Girardin SE, McCoy KD, Macpherson AJ, Paige CJ, Gommerman JL.
Nature. 2011 Dec 11;481(7380):199-203. [PubMed]

120228 田中
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.
Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, Dang CV,Pardoll DM, Pan F.
Cell. 2011 Sep 2;146(5):772-84. [PubMed]

120221 秋田
Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation.
Huang G, Wang Y, Vogel P, Kanneganti TD, Otsu K, Chi H.
Nat Immunol. 2012 Jan 8;13(2):152-61. [PubMed]

120214 大野
Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine.
Shaw MH, Kamada N, Kim YG, Núñez G.
J Exp Med. 2012 Feb 13;209(2):251-8. [PubMed]

120207 上田
Functional innervation of hepatic iNKT cells is immunosuppressive following stroke.
Wong CH, Jenne CN, Lee WY, Léger C, Kubes P.
Science. 2011 Oct 7;334(6052):101-5. [PubMed]

120124 田中
Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity.
Huh JR, Leung MW, Huang P, Ryan DA, Krout MR, Malapaka RR, Chow J, Manel N, Ciofani M, Kim SV, Cuesta A, Santori FR, Lafaille JJ, Xu HE, Gin DY,Rastinejad F, Littman DR.
Nature. 2011 Apr 28;472(7344):486-90. [PubMed]

120117 大野
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation.
Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, Gao X, Aldape K, Lu Z.
Nature. 2011 Dec 1;480(7375):118-22. [PubMed]

110722 上田
Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice.
Oh K, Park HB, Byoun OJ, Shin DM, Jeong EM, Kim YW, Kim YS, Melino G, Kim IG, Lee DS.
J Exp Med. 2011 Aug 1;208(8):1707-19. [PubMed]

110705 田中
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.
Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM.
Science. 2011 Apr 8;332(6026):243-7. [PubMed]

110628 秋田
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. 
Ise W, Kohyama M, Schraml BU, Zhang T, Schwer B, Basu U, Alt FW, Tang J, Oltz EM, Murphy TL, Murphy KM.
Nat Immunol. 2011 Jun;12(6):536-43. [PubMed]

110621 大野
Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation
Jenkins SJ, Ruckerl D, Cook PC, Jones LH, Finkelman FD, van Rooijen N, MacDonald AS, Allen JE.
Science. 2011 Jun 10;332(6035):1284-8. [PubMed]

110614 上田
Invariant NKT cells are required for airway inflammation induced by environmental antigens.
Wingender G, Rogers P, Batzer G, Lee MS, Bai D, Pei B, Khurana A, Kronenberg M, Horner AA.
J Exp Med. 2011 Jun 6;208(6):1151-62. [PubMed]

110607 秋田
The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.
El-Behi M, Ciric B, Dai H, Yan Y, Cullimore M, Safavi F, Zhang GX, Dittel BN, Rostami A.
Nat Immunol. 2011 Jun;12(6):568-75. [PubMed]

110531 田中
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.
Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel G, Yoshimura A, Reindl W, Sipos B, Akira S, Schmid RM, Algül H.
Cancer Cell. 2011 Apr 12;19(4):456-69. [PubMed]

110524 大野
p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2.
Kim T, Veronese A, Pichiorri F, Lee TJ, Jeon YJ, Volinia S, Pineau P, Marchio A, Palatini J, Suh SS, Alder H, Liu CG, Dejean A, Croce CM.
J Exp Med. 2011 May 9;208(5):875-83. [PubMed]

110517 上田
Caspase signalling controls microglia activation and neurotoxicity.
Burguillos MA, Deierborg T, Kavanagh E, Persson A, Hajji N, Garcia-Quintanilla A, Cano J, Brundin P, Englund E, Venero JL, Joseph B.
Nature. 2011 Apr 21;472(7343):319-24. [PubMed]

110510 田中
CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3.
Chen J, Yao Y, Gong C, Yu F, Su S, Chen J, Liu B, Deng H, Wang F, Lin L, Yao H, Su F, Anderson KS, Liu Q, Ewen ME, Yao X, Song E.
Cancer Cell. 2011 Apr 12;19(4):541-55. [PubMed]

110426 田中
 Fate mapping of IL-17-producing T cells in inflammatory responses.
Hirota K, Duarte JH, Veldhoen M, Hornsby E, Li Y, Cua DJ, Ahlfors H, Wilhelm C, Tolaini M, Menzel U, Garefalaki A, Potocnik AJ, Stockinger B.
Nat Immunol. 2011 Mar;12(3):255-63. [PubMed]

110419 大野
ECM1 controls T(H)2 cell egress from lymph nodes through re-expression ofS1P(1).
Li Z, Zhang Y, Liu Z, Wu X, Zheng Y, Tao Z, Mao K, Wang J, Lin G, Tian L, Ji Y, Qin M, Sun S, Zhu X, Sun B.
Nat Immunol. 2011 Feb;12(2):178-85. [PubMed]

110412 上田
Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo.
Oschatz C, Maas C, Lecher B, Jansen T, Björkqvist J, Tradler T, Sedlmeier R, Burfeind P, Cichon S, Hammerschmidt S, Müller-Esterl W, Wuillemin WA, Nilsson G, Renné T.
Immunity. 2011 Feb 25;34(2):258-68. [PubMed]

2010

110329 田中
HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.
Rolny C, Mazzone M, Tugues S, Laoui D, Johansson I, Coulon C, Squadrito ML, Segura I, Li X, Knevels E, Costa S, Vinckier S, Dresselaer T, Åkerud P, De Mol M, Salomäki H, Phillipson M,Wyns S, Larsson E, Buysschaert I, Botling J, Himmelreich U, Van Ginderachter JA, De Palma M, Dewerchin M, Claesson-Welsh L, Carmeliet P.
Cancer Cell. 2011 Jan 18;19(1):31-44. [PubMed]

110322 大野
Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons.
Gregorio J, Meller S, Conrad C, Di Nardo A, Homey B, Lauerma A, Arai N, Gallo RL, Digiovanni J, Gilliet M.
J Exp Med. 2010 Dec 20;207(13):2921-30. [PubMed]

110315 秋田
IL-23-mediated psoriasis-like epidermal hyperplasia is dependent on IL-17A.
Rizzo HL, Kagami S, Phillips KG, Kurtz SE, Jacques SL, Blauvelt A.
J Immunol. 2011 Feb 1;186(3):1495-502. [PubMed]

110222 上田
Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. 
Tan W, Zhang W, Strasner A, Grivennikov S, Cheng JQ, Hoffman RM, Karin M.
Nature. 2011 Feb 24;470(7335):548-53. [PubMed]

110215 田中
Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma.
Chao MP, Alizadeh AA, Tang C, Myklebust JH, Varghese B, Gill S, Jan M, Cha AC, Chan CK, Tan BT, Park CY, Zhao F, Kohrt HE, Malumbres R, Briones J, Gascoyne RD, Lossos IS, Levy R, Weissman IL, Majeti R.
Cell. 2010 Sep 3;142(5):699-713. [PubMed]

100914 大野
Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.
Buonocore S, Ahern PP, Uhlig HH, Ivanov II, Littman DR, Maloy KJ, Powrie F.
Nature. 2010 Apr 29;464(7293):1371-5. [PubMed]

100907 上田
Cross talk between the bone and immune systems: osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells.
Li H, Hong S, Qian J, Zheng Y, Yang J, Yi Q.
Blood. 2010 Jul 15;116(2):210-7.  [PubMed]

100720 田中
Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells.
Schumann K, Lämmermann T, Bruckner M, Legler DF, Polleux J, Spatz JP, Schuler G, Förster R, Lutz MB, Sorokin L, Sixt M.
Immunity. 2010 May 28;32(5):703-13.  [PubMed]

100713 大野
A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth.
Roesch A, Fukunaga-Kalabis M, Schmidt EC, Zabierowski SE, Brafford PA, Vultur A, Basu D, Gimotty P, Vogt T, Herlyn M.
Cell. 2010 May 14;141(4):583-94.  [PubMed]

100629 上田
Calcineurin regulates innate antifungal immunity in neutrophils.
Greenblatt MB, Aliprantis A, Hu B, Glimcher LH.
J Exp Med. 2010 May 10;207(5):923-31. [PubMed]

100622 田中
Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs.
Sugahara KN, Teesalu T, Karmali PP, Kotamraju VR, Agemy L, Greenwald DR, Ruoslahti E.
Science. 2010 May 21;328(5981):1031-5. Epub 2010 Apr 8.  [PubMed]

100615 大野
CD95 promotes tumour growth.
Chen L, Park SM, Tumanov AV, Hau A, Sawada K, Feig C, Turner JR, Fu YX, Romero IL, Lengyel E, Peter ME.
Nature. 2010 May 27;465(7297):492-6.  [PubMed]

100608 上田
Complement drives Th17 cell differentiation and triggers autoimmune arthritis.
Hashimoto M, Hirota K, Yoshitomi H, Maeda S, Teradaira S, Akizuki S, Prieto-Martin P, Nomura T, Sakaguchi N, Köhl J, Heyman B, Takahashi M, Fujita T, Mimori T, Sakaguchi S.
J Exp Med. 2010 Jun 7;207(6):1135-43.  [PubMed]

100601 田中
Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21.
Shields JD, Kourtis IC, Tomei AA, Roberts JM, Swartz MA.
Science. 2010 May 7;328(5979):749-52. Epub 2010 Mar 25.  [PubMed]

100525 大野
Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses.
Villablanca EJ, Raccosta L, Zhou D, Fontana R, Maggioni D, Negro A, Sanvito F, Ponzoni M, Valentinis B, Bregni M, Prinetti A, Steffensen KR, Sonnino S, Gustafsson JA, Doglioni C, Bordignon C, Traversari C, Russo V.
Nat. Med., 16, 98-105, 2010  [PubMed]

100518 上田
Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy.
Browne CD, Del Nagro CJ, Cato MH, Dengler HS, Rickert RC.
IImmunity. 2009 Nov 20;31(5):749-60.  [PubMed]

100511 田中
Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases.
Dupaul-Chicoine J, Yeretssian G, Doiron K, Bergstrom KS, McIntire CR, LeBlanc PM, Meunier C, Turbide C, Gros P, Beauchemin N, Vallance BA, Saleh M.
Immunity. 2010 Mar 26;32(3):367-78. Epub 2010 Mar 11.  [PubMed]

100427 秋田
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.
Stewart CR, Stuart LM, Wilkinson K, van Gils JM, Deng J, Halle A, Rayner KJ, Boyer L, Zhong R, Frazier WA, Lacy-Hulbert A, Khoury JE, Golenbock DT, Moore KJ.
Nat Immunol. 2010 Feb;11(2):155-61. [PubMed]

100413 大野
Lymphotoxin beta receptor signaling in intestinal epithelial cells orchestrates innate immune responses against mucosal bacterial infection.
Wang Y, Koroleva EP, Kruglov AA, Kuprash DV, Nedospasov SA, Fu YX, Tumanov AV.
Immunity. 2010 Mar 26;32(3):403-13.  [PubMed]

2009

100330 上田
Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy.
Browne CD, Del Nagro CJ, Cato MH, Dengler HS, Rickert RC. 
Immunity. 2009 Nov 20;31(5):749-60.  [PubMed]

100323 田中
CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help.
Nakanishi Y, Lu B, Gerard C, Iwasaki A.
Nature. 2009 Nov 26;462(7272):510-3.   [PubMed]

100316 秋田

100309 大野
Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions.
Schulz O, Jaensson E, Persson EK, Liu X, Worbs T, Agace WW, Pabst O.
J Exp Med. 2009 Dec 21;206(13):3101-14.    [PubMed]

100302 上田
CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients.
Blair PA, Noreña LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, Mauri C.
Immunity. 2010 Jan 29;32(1):129-40. [PubMed]

100223 田中
Enhancing CD8 T-cell memory by modulating fatty acid metabolism.
Pearce EL, Walsh MC, Cejas PJ, Harms GM, Shen H, Wang LS, Jones RG, Choi Y.
Nature. 2009 Jul 2;460(7251):103-7   [PubMed]

100216 大野
Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning.
Pham TH, Baluk P, Xu Y, Grigorova I, Bankovich AJ, Pappu R, Coughlin SR, McDonald DM, Schwab SR, Cyster JG.
J Exp Med. 2010 Jan 18;207(1):17-27.  [PubMed]

100209 上田
Innate production of Th2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells.
Moro K, Yamada T, Tanabe M, Takeuchi T, Ikawa T, Kawamoto H, Furusawa J, Ohtani M, Fujii H, Koyasu S.
Nature. 2010 Jan 28;463(7280):540-4.  [PubMed]

100202 田中
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.
Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA.
Nat Immunol. 2009 Nov;10(11):1185-92.   [PubMed]

100126 秋田
CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms.
Ise W, Kohyama M, Nutsch KM, Lee HM, Suri A, Unanue ER, Murphy TL, Murphy KM.
Nat Immunol. 2010 Feb;11(2):129-35. [PubMed]

100112 大野
Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury.
Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, Wu ZR, Hooper LV, Schmidt RR, von Aulock S, Radek KA, Huang CM, Ryan AF, Gallo RL.
Nat Med. 2009 Dec;15(12):1377-82.   [PubMed]

090929 上田
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance.
Elliott MR, Chekeni FB, Trampont PC, Lazarowski ER, Kadl A, Walk SF, Park D, Woodson RI, Ostankovich M, Sharma P, Lysiak JJ, Harden TK, Leitinger N, Ravichandran KS.
Nature. 2009 Sep 10;461(7261):282-6.  [PubMed]

090915 田中
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters.
Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, Lee J, Goldfine AB, Benoist C, Shoelson S, Mathis D.
Nat Med. 2009 Aug;15(8):930-9.   [PubMed]

090908 秋田
The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.
Liu G, Burns S, Huang G, Boyd K, Proia RL, Flavell RA, Chi H.
Nat Immunol. 2009 Jul;10(7):769-77.  [PubMed]

090901 大野
Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10.
Ilarregui JM, Croci DO, Bianco GA, Toscano MA, Salatino M, Vermeulen ME, Geffner JR, Rabinovich GA.
Nat Immunol. 2009 Sep;10(9):981-91.    [PubMed]

090721 上田
A role for human skin-resident T cells in wound healing.
Toulon A, Breton L, Taylor KR, Tenenhaus M, Bhavsar D, Lanigan C, Rudolph R, Jameson J, Havran WL.
J Exp Med. 2009 Apr 13;206(4):743-50.  [PubMed]

090707 田中
Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response.
Sokol CL, Chu NQ, Yu S, Nish SA, Laufer TM, Medzhitov R.
Nat Immunol. 2009 Jul;10(7):713-20.   [PubMed]

090630 秋田
Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus.
Doreau A, Belot A, Bastid J, Riche B, Trescol-Biemont MC, Ranchin B, Fabien N, Cochat P, Pouteil-Noble C, Trolliet P, Durieu I, Tebib J, Kassai B, Ansieau S, Puisieux A, Eliaou JF, Bonnefoy-Bérard N
Nat Immunol. 2009 Jul;10(7):778-85.   [PubMed]

090623 大野
A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis.
Valastyan S, Reinhardt F, Benaich N, Calogrias D, Szász AM, Wang ZC, Brock JE, Richardson AL, Weinberg RA.
Cell. 2009 Jun 12;137(6):1032-46.   [PubMed]

090616 上田
Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome.
Minegishi Y, Saito M, Nagasawa M, Takada H, Hara T, Tsuchiya S, Agematsu K, Yamada M, Kawamura N, Ariga T, Tsuge I, Karasuyama H.
J Exp Med. 2009 Jun 8;206(6):1291-301. Epub 2009 Jun 1.   [PubMed]

090609 田中
Conduits mediate transport of low-molecular-weight antigen to lymph node follicles.
Roozendaal R, Mempel TR, Pitcher LA, Gonzalez SF, Verschoor A, Mebius RE, von Andrian UH, Carroll MC.
Immunity. 2009 Feb;30(2):264-76.   [PubMed]

090512 大野
Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses.
Nakano H, Lin KL, Yanagita M, Charbonneau C, Cook DN, Kakiuchi T, Gunn MD.
Nat Immunol. 2009 Apr;10(4):394-402.   [PubMed]

090428 上田
The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function.
Locci M, Draghici E, Marangoni F, Bosticardo M, Catucci M, Aiuti A, Cancrini C, Marodi L, Espanol T, Bredius RG, Thrasher AJ, Schulz A, Litzman J, Roncarolo MG, Casorati G, Dellabona P, Villa A.
J Exp Med. 2009 Apr 13;206(4):735-42.  [PubMed]

090421 田中
A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
Chen S, Borowiak M, Fox JL, Maehr R, Osafune K, Davidow L, Lam K, Peng LF, Schreiber SL, Rubin LL, Melton D.
Nat Chem Biol. 2009 Apr;5(4):258-65. Epub 2009 Mar 15.   [PubMed]

090414 大野
Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells.
Colmone A, Amorim M, Pontier AL, Wang S, Jablonski E, Sipkins DA.
Science. 2008 Dec 19;322(5909):1861-5.   [PubMed]

090407 上田
Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.
Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R.
J Exp Med. 2009 Mar 16;206(3):535-48.    [PubMed]

2008

090331 田中
Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression.
Godar S, Ince TA, Bell GW, Feldser D, Donaher JL, Bergh J, Liu A, Miu K, Watnick RS, Reinhardt F, McAllister SS, Jacks T, Weinberg RA
Cell. 2008 Jul 11;134(1):62-73.   [PubMed]

090317 大野
Efficient tumour formation by single human melanoma cells.
Quintana E, Shackleton M, Sabel MS, Fullen DR, Johnson TM, Morrison SJ.
Nature. 2008 Dec 4;456(7222):593-8.   [PubMed]
 
090303 上田
NKT cell-plasmacytoid dendritic cell cooperation via OX40 controls viral infection in a tissue-specific manner.
Diana J, Griseri T, Lagaye S, Beaudoin L, Autrusseau E, Gautron AS, Tomkiewicz C, Herbelin A, Barouki R, von Herrath M, Dalod M, Lehuen A.
Immunity. 2009 Feb 20;30(2):289-99.   [PubMed]

090224 田中
Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment.
Choi EY, Chavakis E, Czabanka MA, Langer HF, Fraemohs L, Economopoulou M, Kundu RK, Orlandi A, Zheng YY, Prieto DA, Ballantyne CM, Constant SL, Aird WC, Papayannopoulou T, Gahmberg CG, Udey MC, Vajkoczy P, Quertermous T, Dimmeler S, Weber C, Chavakis T.
Science. 2008 Nov 14;322(5904):1101-4.   [PubMed]

090217 大野
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis.
Ishii M, Egen JG, Klauschen F, Meier-Schellersheim M, Saeki Y, Vacher J, Proia RL, Germain RN.
Nature. 2009 Mar 26;458(7237):524-8.   [PubMed]

090210 上田
Curcumin suppresses the induction of indoleamine 2,3-dioxygenase by blocking the Janus-activated kinase-protein kinase Cdelta-STAT1 signaling pathway in interferon-gamma-stimulated murine dendritic cells.
Jeong YI, Kim SW, Jung ID, Lee JS, Chang JH, Lee CM, Chun SH, Yoon MS, Kim GT, Ryu SW, Kim JS, Shin YK, Lee WS, Shin HK, Lee JD, Park YM.
J Biol Chem. 2009 Feb 6;284(6):3700-8.   [PubMed]

090203 田中
Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche.
Lo Celso C, Fleming HE, Wu JW, Zhao CX, Miake-Lye S, Fujisaki J, Côté D, Rowe DW, Lin CP, Scadden DT.
Nature. 2009 Jan 1;457(7225):92-6.   [PubMed]

090127 大野
Cutting edge: Autocrine TGF-beta sustains default tolerogenesis by IDO-competent dendritic cells.
Belladonna ML, Volpi C, Bianchi R, Vacca C, Orabona C, Pallotta MT, Boon L, Gizzi S, Fioretti MC, Grohmann U, Puccetti P.
J Immunol., 2008, 181: 5194–8   [PubMed]

081209 免疫学会報告会

081125 上田
Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation.
Stout-Delgado HW, Yang X, Walker WE, Tesar BM, Goldstein DR.
J Immunol. 2008 Nov 15;181(10):6747-56.  [PubMed]

081118 田中
Plasmacytoid dendritic cells mediate oral tolerance.
Goubier A, Dubois B, Gheit H, Joubert G, Villard-Truc F, Asselin-Paturel C, Trinchieri G, Kaiserlian D.
Immunity. 2008 Sep;29(3):464-75.   [PubMed]

081111 大野
Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo.
Hammerschmidt SI, Ahrendt M, Bode U, Wahl B, Kremmer E, Förster R, Pabst O.
J Exp Med. 2008 Oct 27;205(11):2483-90.  [PubMed]

080930 上田
Adenosine receptors in regulation of dendritic cell differentiation and function.
Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM.
Blood. 2008 Sep 1;112(5):1822-31.    [PubMed]

080916 田中
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.
Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S.
Nat Immunol. 2008 Jul;9(7):769-76.   [PubMed]

080909 大野
A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses.
Nochi T, Yuki Y, Matsumura A, Mejima M, Terahara K, Kim DY, Fukuyama S, Iwatsuki-Horimoto K, Kawaoka Y, Kohda T, Kozaki S, Igarashi O, Kiyono H.
J Exp Med. 2007 Nov 26;204(12):2789-96.  [PubMed]

080729 上田
A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation.
Braun D, Longman RS, Albert ML.
Blood. 2005 Oct 1;106(7):2375-81.    [PubMed]

080722 田中
The epithelial-mesenchymal transition generates cells with properties of stem cells.
Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL, Polyak K, Brisken C, Yang J, Weinberg RA.
Cell. 2008 May 16;133(4):704-15.   [PubMed]

080715 大野
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid.
Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, Cheroutre H.
Science. 2007 Jul 13;317(5835):256-60.    [PubMed]

080701 上田
Cutting edge: Peyer’s patch plasmacytoid dendritic cells (pDCs) produce low levels of type I interferons: possible role for IL-10, TGF, and prostaglandin E2 in conditioning a unique mucosal pDC phenotype.
Contractor N, Louten J, Kim L, Biron CA, Kelsall BL.
J Immunol. 2007 Sep 1;179(5):2690-4.   [PubMed]

080624 田中
A microbial symbiosis factor prevents intestinal inflammatory disease
Mazmanian SK, Round JL, Kasper DL.
Nature. 2008 May 29;453(7195):620-5.   [PubMed]

080609 大野
TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis.
Sun H, Gong S, Carmody RJ, Hilliard A, Li L, Sun J, Kong L, Xu L, Hilliard B, Hu S, Shen H, Yang X, Chen YH.
Cell. 2008 May 2;133(3):415-26   [PubMed]

080603 上田
“ Re-educating ” tumor-associated macrophages by targeting NF-kappaB.
Hagemann T, Lawrence T, McNeish I, Charles KA, Kulbe H, Thompson RG, Robinson SC, Balkwill FR.
J Exp Med. 2008 Jun 9;205(6):1261-8.   [PubMed]

080527 田中
S1P1 receptor signaling overrides retention mediated by G α i-coupled receptors to promote T cell egress.
Pham TH, Okada T, Matloubian M, Lo CG, Cyster JG.
Immunity. 2008 Jan;28(1):122-33.  [PubMed]