兵庫医療大学　薬学部
生体防御学研究室
Laboratory of Immunobiology, School of Pharmacy, Hyogo University of Health Sciences


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兵庫医療大学HPへ
薬学部HPへ
Publication 


原著論文・総説


2012
  1. Hara K., Ueda S., Ohno Y., Tanaka T., Yagi H., Okazaki S., Kawahara R., Masayuki T., Enomoto T., Hashimoto Y., Masuko K. & Masuko T. NIH3T3 cells over-expressing CD98 heavy chain resist early G1 arrest and apoptosis induced by serum starvation. Cancer Sci., 103, 1460-6, 2012
  2. Masuko .K, Okazaki S., Satoh M., Tanaka G., Ikeda T., Torii R., Ueda E., Nakano T., Danbayashi M., Tsuruoka T., Ohno Y., Yagi H., Yabe N., Yoshida H., Tahara T., Kataoka S., Oshino T., Shindo T., Niwa S., Ishimoto T., Baba H., Hashimoto Y., Saya H. & Masuko T. Anti-tumor effect against human cancer xenografts by a fully human monoclonal antibody to a variant 8-epitope of CD44R1 expressed on cancer stem cells. PLoS One, 7, e29728, 2012


2011
  1. Ohkawa M., Ohno Y., Masuko K., Takeuchi A., Suda K., Kubo A., Kawahara R., Okazaki S., Tanaka T., Saya H., Seki M., Enomoto T., Yagi H., Hashimoto Y. & Masuko T. Oncogenicity of L-type amino-acid transporter 1 (LAT1) revealed by targeted gene disruption in chicken DT40 cells: LAT1 is a promising molecular target for human cancer therapy. Biochem. Biophys. Res. Commun., 406:649-55, 2011.
  2. Masuko T., Ohno Y., Masuko K., Yagi H., Uejima S., Takechi M. & Hashimoto Y. Towards therapeutic antibodies to membrane oncoproteins by a robust strategy using rats immunized with transfectants expressing target molecules fused to green fluorescent protein. Cancer Sci., 102:25-35, 2011..
  3. Satoh K., Takahashi H., Matsuda C.,Tanaka T., Miyasaka M., Zeniya M., & Kohara M.:Natural killer cells target HCV core proteins during the innate immune response in HCV transgenic mice. J Med Virol., 82:1545-53, 2010.
  4. Li W., Kubo S., Okuda A., Yamamoto H., Ueda H., Tanaka T., Nakamura H., Yamanishi H., Terada M. & Okamura H.: Effect of IL-18 on expression of gammadelta T cells stimulated by zoledronate and IL-2.　J Immunother., 33:287-96, 2010

  5. Matsui K., Ueda H., Terada M., Azuma N., Okamura H. & Sano H.: Mizoribine protects against bleomycin-induced lung injury. Mol Rheumatol., 20, 471-7, 2011
  6. Masuko T., Ohno Y., Masuko K., Yagi H., Uejima S., Takechi M. & Hashimoto Y.: Towards therapeutic antibodies to membrane oncoproteins by a robust strategy using rats immunized with transfectants expressing target molecules fused to green fluorescent protein. Cancer Sci., 102、25-35, 2011


2010
  1. Kikushige, Y., Shima, T., Takayanagi, S., Urata, S., Miyamoto, T., Iwasaki, H., Takenaka, K.,Teshima, T., Tanaka, T., Inagaki, Y., & *Akashi, K. TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells. Cell Stem Cell, 7:708-717, 2010.
  2. Ebisuno Y., Katagiri K., Katakai T., Ueda Y., Nemoto T., Inada H., Nabekura J., Okada T., Kannagi R., Tanaka T., Miyasaka M., Hogg N., & Kinashi T.Rap1 contrtol lymphocyte adhesion cascades and interstitial migration within lymph nodes in RAPL-dependent and -independent manners. Blood., 115:804-14, , 2010.

  3. Tanaka T., Moriwaki K., Murata S., & Miyasaka M. A LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin. Cancer Sci., 101:363-8, 2010.
  4. Satoh K., Takahashi H., Matsuda C., Tanaka T., Miyasaka M., Zeniya M., & Kohara M.:Natural killer cells target HCV core proteins during the innate immune response in HCV transgenic mice. J Med Virol., 82:1545-53, 2010.
  5. Li W., Kubo S., Okuda A., Yamamoto H., Ueda H., Tanaka T., Nakamura H., Yamanishi H., Terada M. & Okamura H.: Effect of IL-18 on expression of gammadelta T cells stimulated by zoledronate and IL-2.　J Immunother., 33:287-96, 2010

  6. Matsui K., Ueda H., Terada M., Azuma N., Okamura H. & Sano H.: Mizoribine protects against bleomycin-induced lung injury. Mol Rheumatol., in press
  7. Masuko T., Ohno Y., Masuko K., Yagi H., Uejima S., Takechi M. & Hashimoto Y.: Towards therapeutic antibodies to membrane oncoproteins by a robust strategy using rats immunized with transfectants expressing target molecules fused to green fluorescent protein. Cancer Sci., in press


2009
  1. Yokoyama S., Watanabe N., Sato N., Filkoski L., Tanaka T., Miyasaka M., Waldmann T.A., Hiroi T. & *Perera L.P.: Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes. Proc. Natl. Acad. Sci. U. S. A., 106:15849-15854, 2009.
  2. Inokuchi C., Ueda H., Hamaguchi T., Miyagawa J., Shinohara M., Okamura H. & *Namba M.: Role of macrophages in the development of pancreatic islet injury in spontaneously diabetic torii rats. Exp Anim., 58:383-94, 2009.


2008
  1. Nakasaki T, Tanaka T, Okudaira S, Hirosawa M, Umemoto E, Otani K, Jin S, Bai Z, Hayasaka H, Fukui Y, Aozasa K, Fujita N, Tsuruo T, Ozono K, Aoki J, & Miyasaka M., Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions. Am. J. Pathol., 173: 1566-76, 2008
  2. Sugahara KN, Hirata T, Tanaka T, Ogino S, Takeda M, Terasawa H, Shimada I, Tamura J, ten Dam GB, van Kuppevelt TH, & Miyasaka M., Chondroitin sulfate E fragments enhance CD44 cleavage and CD44-dependent motility in tumor cells., Cancer Res., 68: 7191-9, 2008
  3. Jin S, Umemoto E, Tanaka T, Shimomura Y, Tohya K, Kunizawa K, Yang BG, Jang MH, Hirata T, & Miyasaka M., Nepmucin/CLM-9, an Ig domain-containing sialomucin in vascular endothelial cells, promotes lymphocyte transendothelial migration in vitro. FEBS Lett., 582: 3018-24, 2008
  4. Thompson LF, Takedachi M, Ebisuno Y, Tanaka T, Miyasaka M, Mills JH, & Bynoe MS., Regulation of leukocyte migration across endothelial barriers by ECTO-5'-nucleotidase-generated adenosine. Nucleosides Nucleotides Nucleic Acids., 27: 755-60, 2008
  5. Takedachi M, Qu D, Ebisuno Y, Oohara H, Joachims ML, McGee ST, Maeda E, McEver RP, Tanaka T, Miyasaka M, Murakami S, Krahn T, Blackburn MR, Thompson LF., CD73-generated adenosine restricts lymphocyte migration into draining lymph nodes., J. Immunol. 180: 6288-96, 2008

  6. Hosotani Y, Kashiwamura S, Kimura-Shimmyo A, Sekiyama A, Ueda H, Ikeda T, Mimura O, Okamura H., Interleukin-18 prevents apoptosis via PI3K/Akt pathway in normal human keratinocytes., J. Dermatol. 8: 514-24, 2008.
  7. Hirata J, Kotani J, Aoyama M, Kashiwamura S, Ueda H, Kuroda Y, Usami M, Okamura H, Marukawa S., A role for IL-18 in human neutrophil apoptosis., Shock, 6: 628-33, 2008.
  8. Watanabe H, Hata M, Terada N, Ueda H, Yamada N, Yamanegi K, Ohyama H, Kakihana M, Okamura H, Nakasho K., Transdifferentiation into biliary ductular cells of hepatocytes transplanted into the spleen., Pathology, 3: 272-6, 2008.
  9. Nishio S, Yamada N, Ohyama H, Yamanegi K, Nakasho K, Hata M, Nakamura Y, Fukunaga S, Futani H, Yoshiya S, Ueda H, Taniguchi M, Okamura H, Terada N., Enhanced suppression of pulmonary metastasis of malignant melanoma cells by combined administration of alpha-galactosylceramide and interleukin-18., Cancer Sci., 1: 13-20, 2008.
  10. Ohno Y, Yagi H, Nakamura M, Masuko K, Hashimoto Y, & Masuko T., Cell-Death-Inducing Monoclonal Antibodies Raised against DT40 Tumor Cells: Identification of Chicken Transferrin Receptor as a Novel Cell-Death Receptor. Cancer Sci., 99: 894-900, 2008.
  11. Ohno Y, Yagi H, Nakamura M, Masuko K, Hashimoto Y, & Masuko T., Simultaneous Induction of Apoptotic, Autophagic, and Necrosis-like Cell Death by Monoclonal Antibodies Recognizing Chicken Transferrin Receptor. Biochem. Biophys. Res. Commun., 367: 775-781, 2008.
  12. Ohno Y, Suda K, Yagi H, Masuko K, Hashimoto Y, & Masuko T., Production and Characterization of Highly Tumor-Specific Rat Monoclonal Antibodies Recognizing the Extracellular Domain of Human LAT1 Amino-acid Transporter. Cancer Sci., 99: 1000-1007, 2008.


2007
  1. Yang B.-G., Tanaka T., Jang M.H., Bai Z., Hayasaka H. & Miyasaka, M., Binding of lymphoid chemokines to collagen IV that accumulates in the basal lamina of high endothelial venules; its implication in lymphocyte trafficking. J. Immunol., 179: 4376-4382, 2007.
  2. *Matsutani T., *Tanaka T., Tohya K., Otani K., Jang M.H., Umemoto E., Taniguchi K., Hayasaka H., Ueda K. & Miyasaka M. (*equal contribution), Plasmacytoid dendritic cells employ multiple cell adhesion molecules sequentially to interact with high endothelial venule cells - Molecular basis of their trafficking to lymph nodes., Int. Immunol., 9: 1031-1037, 2007.
  3. Matsumoto M., Shigeta A., Furukawa Y., Tanaka T., Miyasaka M. & Hirata T., CD43 collaborates with P-selectin glycoprotein ligand-1 to mediate E-selectin-dependent T cell migration into inflamed skin. J. Immunol., 178: 2499-2506, 2007.

  4. Yotsui T., Yasuda O., Kawamoto H., Higuchi M., Chihara Y., Umemoto E., Tanaka T. Miyasaka M., Rakugi H. & Ogihara T., Aspirin prevents adhesion of T lymphoblasts to vascular smooth muscle cells. FEBS Lett., 581: 427-432, 2007.

  5. Oku H, Ogawa Y, Iwaoka E, Kunitomo M, Ueda H, Okamura H, Ishiguro K., Involvement of inducible nitric oxide synthase in blood flow decrease in vein induced by hen-egg white lysozyme., Biol. Pharm. Bull., 7: 1324-8, 2007.
  6. Li W, Kashiwamura S, Ueda H, Sekiyama A, Okamura H., Protection of CD8+ T cells from activation-induced cell death by IL-18., J. Leukoc. Biol., 82: 142-51, 2007.
  7. Seino H, Ueda H, Kokai M, Tsuji NM, Kashiwamura S, Morita Y, Okamura H., IL-18 mediates the formation of stress-induced, histamine-dependent gastric lesions., Am. J. Physiol. Gastrointest. Liver Physiol., 292: 262-7, 2007.